モルホリン系抗真菌剤Ａｍｏｒｏｌｆｉｎｅの作用についての電子顕微鏡学的解析　Ｔｒｉｃｈｏｐｈｙｔｏｎ　ｍｅｎｔａｇｒｏｐｈｙｔｅｓ発育菌糸形態に及ぼす影響

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  • Effect of Amorolfine, a New Antifungal Agent, on the Ultrastructure of Trichophyton mentagrophytes.
  • Trichophyton mentagrophytes発育菌糸形態に及ぼす影響

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Amorolfine (MT-861), a new class of morpholine derivative, is an antifungal agent with high activity against dermatophytes, pathogenic yeasts and filamentous fungi. In this study, the effect of MT-861 on the ultrastructure of hyphae of Trichophyton mentagrophytes in a liquid medium was investigated by scanning and transmission electron microscopy. Hyphal growth was inhibited at the drug concentration of 0.8ng/ml, and several morphological changes such as waving of the surface structure and contour deformation were observed. In thin sections, accumulation of electron dense granular structures formed within both the wall and the cytoplasmic membrane was visible. With 80ng/ml of MT-861, collapsed and distorted hyphae and exfoliation of surface structures were also observed. Moreover, degeneration of the cytoplasmic membrane and alteration of organelles were clearly seen at this concentration of the drug. From these results, it is concluded that ultrastructural changes caused by MT-861 lead to the death of fungal hyphae.

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