実験白せんの成立条件と皮膚構造の病像形成への関与―モルモット背部，モルモット足底，ヘアレスモルモット背部皮膚における実験白せんの病像の比較

• 藤田 繁

  新潟大学医学部皮膚科学教室

書誌事項

タイトル別名

• Conditions required for successful experimental dermatophytosis and its histopathogenesis.

抄録

Experimental dermatophytoses, which mimic the skin manifestations of human dermatophytoses may be good animal models to elucidate the histopathogenesis of the characteristic features of the human dermatophytoses such as “athlete's foot” and “ring worm”. In the experimental models it is always required that animals constantly form skin lesions with similar clinical appearance and course to those of human dermatophytoses after the inoculation of fungi. Experimental dermatophytoses on the backs of hairy guinea pigs generated by zoophilic strains of Trichophyton mentagrophytes have been used as first choice models, but they are quite different from human dermatophytoses, clinically, histologically and especially in their selfhealing courses. Zoophilic strains of T. mentagrophytes can infect guinea pig skin after 24 hours occlusion. However, anthropophilic strains may require a longer occlusion periods for infection.<br>In the present study, experimentally induced lesions on the plantar parts of guinea pigs with T. mentagrophytes zoophilic strain SM-110 closely resembled human tinea pedis clinically and histologically. On the other hand, the SM-110 generated lesions on the backs of hairless guinea pigs also resmbled human tinea corporis. In the histopathogenesis of dermatophytoses, skin structures of the infected or inoculated site seem to be important as well as strains of the dermatophytes.

収録刊行物

• 日本医真菌学会雑誌

  日本医真菌学会雑誌 33 (2), 115-125, 1992

  日本医真菌学会

キーワード

• 実験白癬
• 接種法
• 皮膚構造
• 病像

詳細情報

• CRID: 1390001204211627648
• NII論文ID: 130003671666
• DOI: 10.3314/jjmm.33.115
• ISSN: 18820476
• ISSN: 09164804
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可