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- 鐘野 勝洋
- 千葉大学医学部内科学第二講座
書誌事項
- タイトル別名
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- Disseminated Fusarium solani Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation
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A patient with a hematological malignancy is one example of a type of immunocompromised host, and critical opportunistic infections such as mycosis are not rare during medical treatment for such malignancy.<br>Candidiasis and aspergillosis are typical mycoses and their importance has been recognized widely and great progress attained in their prevention and medical treatment. However, allogenic hematopoietic stem cell transplantation (allo-HSCT) to treat hematological malignancy has spread, and the increase in emerging mycoses such as Fusarium infection is reported.<br>Fusarium spp. are common soil organisms and important plant pathogens, and have been conventionally known as a causative fungus of superficial mycosis in the dermatology and the ophthalmology domain. Reports of profound or disseminated Fusarium infection are found in immunocompromised hosts with such condition as a hematological malignancy or organ transplant, and have shown an upward tendency in recent years.<br>The symptoms of disseminated Fusarium infection are shown in many cases with persistent fever refractory to antibiotics and pneumonia, and this is a highly fatal infection which merges fungemia with multiple organ injury such as that in the lung, liver, spleen, kidney, and the heart. Disseminated Fusarium infection has a high rate of isolation in blood cultures, and the rate of diagnosis while a patient is alive is high compared with aspergillosis, zygomycosis, etc.<br>Despite the administration of anti-fungal drugs following allo-HSCT, two reported cases showing the symptoms of disseminated Fusarium infection finally died. Although definite diagnosis of these cases was made by blood cultures, no medical treatment effect with the anti-fungal drugs was determined. Since the existing antifungals are not expected to cure disseminated Fusarium infection certainly, an early diagnosis and the development of a new antifungal are desired to improve the medical treatment results.
収録刊行物
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- 日本医真菌学会雑誌
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日本医真菌学会雑誌 44 (3), 187-191, 2003
日本医真菌学会
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詳細情報 詳細情報について
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- CRID
- 1390001204213077376
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- NII論文ID
- 130003672063
- 50000276059
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- NII書誌ID
- AN10166867
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- COI
- 1:STN:280:DC%2BD3sznslyisA%3D%3D
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- ISSN
- 18820476
- 09164804
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- PubMed
- 12913807
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可