Blocking Effect of Gynostemma pentaphyllum Makino (GP) on the Point Mutation of Ha-ras Oncogene during Leukoplakia Canceration

• ZHOU Zengtong

  Shanghai Ninth People's Hospital affiliated with Shanghai Second Medical University

• TANG Guoyao

  Shanghai Ninth People's Hospital affiliated with Shanghai Second Medical University

• ZHONG Wenjing

  Shanghai Ninth People's Hospital affiliated with Shanghai Second Medical University

• DING Reiyu

  Shanghai Ninth People's Hospital affiliated with Shanghai Second Medical University

• MAO Hongde

  Research Institute of Shanghai Medical Industry, National Medical Bureau

• HU Hulfang

  Shanghai Ninth People's Hospital affiliated with Shanghai Second Medical University

• FANG Yiru

  Departments of Anesthesiology, Osaka Dental University

• IMAI Hisao

  Departments of Periodontology, Osaka Dental University

• TANAKA Akio

  Departments of Oral Pathology, Osaka Dental University

書誌事項

タイトル別名

• Blocking Effect of <i>Gynostemma pentaphyllum</i> Makino (GP) on the Point Mutation of Ha-<i>ras</i> Oncogene during Leukoplakia Canceration

抄録

In order to elucidate the blocking effect of Gynostemma pentaphyllum Makino (GP), one of the Chinese medicines, on the point mutation of Ha-ras, oral leukoplakia (OLP) induced by dimethylbenzanthracene (DMBA) in the cheek pouch of Syrian hamster was used. GP was taken in the hamsters with OL. Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique and tissue specimens indicating OL, the point mutation of Ha-ras oncogene on codon 61 was investigated. The incidences of point mutation were 22.92% in GP-untreated OL and 7.52% in GP-treated OL (6.25% in the glucoside group, 11.00% in the aglucon group and 5.32% in the C₂₀-OH group). GP might prevent the point mutation of Ha-ras oncogene related to OL canceration. This study also suggests that the hydroxyl ion may be the potent component of GP in the inhibition of canceration.

収録刊行物

• 日本口腔粘膜学会雑誌

  日本口腔粘膜学会雑誌 6 (1), 1-6, 2000

  日本口腔内科学会

キーワード

• <i>Gynostemma pentaphyllum</i> Makino
• Ha-ras oncogene mutation
• Oral leukoplakia canceration

詳細情報

• CRID: 1390282680198929792
• NII論文ID: 130003673758
• DOI: 10.6014/jjomm1995.6.1
• ISSN: 18841473
• ISSN: 13417983
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可