書誌事項
- タイトル別名
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- A Case of Fatal Interstitial Pneumonitis after Paraquat Ingestion
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抄録
A 32-year-old housewife intentionally ingested about 15ml of paraquat, and suffered severe burning epigastric pain and vomiting. The next morning she was admitted to a certain hospital, but gastric lavage was not performed, because the paraquat ingestion was not revealed until that evening. Immediately corticosteroids and purgatives were administered, but from the 6th day she became febrile, cyanotic and edematous. On the 9th day she was transferred to Seirei Hamamatsu Hospital because of high blood nitrogen urea (100mg/dl).<br>She recovered from acute renal failure on the 3rd day after the administration of hydrocortisone and diuretics, but the respiratory status became gradually worse, necessitating the use of increasing concentration of oxygen. Finally, she could not turn in bed and the chest film obtained on the 14th hospital day showed coarse linear, nodular and macular patterns throughout the lungs with diminution of volume. In spite of increasing prednisolone dosage to 60mg, the arterial oxygen partial pressure remained about 30mmHg. She died after sudden severe dyspnea on the 28th hospital day (36 days after ingestion). The postmortem chest roentgenogram showed the pneumothorax in left lung.<br>Gross appearance of the lungs at autopsy showed an irregular outer surface made up of contracted solid areas and residual spongy parenchyma. The histopathological investigation of the lung revealed extensive areas of consolidation resulting from marked and diffuse fibrosis of the alveolar septa accompanied by only sparse infiltration of inflammatory cells. The alveolar spaces appeared to be markedly compressed, but basically were not obliterated. Histological abnormalities in the other organs were as follows; degeneration and hemorrhage of renal tubules, atrophy of the adrenal glands and liver cell degeneration mostly in the central zone of the lobules.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 16 (12), 919-925, 1978
社団法人 日本呼吸器学会