書誌事項
- タイトル別名
-
- A Comparative Study between Functional and Pathologic Alterations in the Lungs of Rabbits Exposed to an Ambient Level of Ozone Functional Aspects
この論文をさがす
抄録
Pulmonary effects produced by exposure to a low concentration of ozone were investigated utilizing 53 pentobarbitalized adult rabbits. Thirty five rabbits respired room air containing ozone ranging frome 0.25 to 1.1ppm for 12hr. The lungs were examined for functional and pathological changes at 6 hrs (15 rabbits), 1 day (7 rabbits), 3 days (6 rabbits), and 7 days (7 rabbits) thereafter. The remaining 18 rabbits were not exposed to ozone and served as controls. Closing volume and lung volumes were measured by use of the single breath oxygen test. Significant changes were observed in the slope of phase III (ΔN2%), closing volume %(CV%), closing capacity %(CC%), residual volume %(RV%), standardized vital capacity (%VC), and standardized residual volume (%RV), though the peak stage of these changes varied for each factor. ΔN2% showed a maximal increase at 6hrs, followed by a rather rapid recovery. In contrast, the CC%, CV%, and RV% attained their highest values at one day and gradually recovered to levels close to control values by seven days. Since the functional changes reported were closely correlated with concurrent pathological findings, we conclude that the former reliably reflect the abnormalities of peripheral airway disease.
収録刊行物
-
- 日本胸部疾患学会雑誌
-
日本胸部疾患学会雑誌 17 (5), 288-297, 1979
社団法人 日本呼吸器学会