骨髄性白血病における赤芽球増殖動態の検討

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タイトル別名
  • A STUDY OF PROLIFERATION KINETICS OF ERYTHROBLASTS IN PATIENTS WITH MYELOID LEUKEMIA
  • コツズイセイ ハッケツビョウ ニ オケル セキガキュウ ゾウショク ドウタイ

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In a study on proliferation kinetics of erythroblasts in myeloid leukemia, the following results were obtained : <BR>1) In the untreated, acute type, the activity of erythropoietin responsive cells (ERC) in the bone marrow was markedly decreased. There was a significant, positive correlation between ERC activity and relative erythroblast counts in the bone marrow. In these cases, the labeling index (LI) with 3H-thymidine of the total erythroblasts was significantly decreased. The decreased in LI was more striking in the cases where the erythroblasts resembling megaloblasts (PAS negative) were found in the bone marrow smears. LI in the basophilic erythroblasts remained within normal range, while the decrease in LI was conspicuous and statistically significant in polychromatic erythroblasts. In remission, ERC activity was raised to normal or above normal. LI was also normalized. The DNA synthesis time of erythroblasts in the untreated acute type was 12.9 + 0.4 hours, which did not differ from that of normal erythroblasts. The decreased LI was, therefore, considered to indicate that the polychromatic erythroblasts had a long G1 phase or that those which got into the G0 phase increased. In these cases, it was revealed that increase in number of erythroblasts with nuclei of small diameter resulted in a decreased labeling index.<BR>2) In chronic myeloid leukemia, ERC activity and LI of erythroblasts showed no particular changes.<BR>3) There occurred no striking changes in the LI of erythroblasts of cancer patients.<BR>4) From the results presented above, it was concluded that there were not only quantitative but also qualitative changes in the erythropoiesis in acute myeloid leukemia.

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