食用色素 Ponceau 3R の慢性毒性ならびに発癌性に関する研究

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タイトル別名
  • Chronic Oral Toxicity and Carcinogenicity of Ponceau 3R
  • ショクヨウ シキソ Ponceau 3R ノ マンセイ ドクセイ ナラビニ ハツガンセイ ニ カンスル ケンキュウ

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Two year feeding experiments of Ponceau 3R (Food Red No. 1) were carried out to ascertain of its chronic oral toxicity and carcinogenicity in rats. Eighty Wistar rats were divided into 4 groups of twenty each (equally divided by sex), and each group was fed at dosage levels of 2.0, 1.0, 0.5% and 0.0% (control). The animals were allowed food and water ad libitum. Food consumption and body weight gains were weighed weekly. Liver biopsy at the 30th and the 53rd week, and autopsy at the 83rd and the 105th week (at the end of experiment) were performed. All these specimens were examined histopathologically and at the end of the experiment blood samples were collected from the tail veins of 2 or 3 animals from each level for blood counts.<br>Results were as follows:<br>Inhibition of body weight gains was observed in all dosage levels, especially in 2.0% level of Ponceau 3R, but food consumption did not show any differences between control and treated groups.<br>Histopathologically, toxic effects and neoplastic changes attributable to Ponceau 3R were limited to liver. From early liver showed marked fatty metamorphoses, hydropic degeneration, acidophilic degeneration, cell edema with decrease or loss of basophilic bodies in the cytoplasm, and single cell necrosis of hepatic cells. Atypical nodular hyperplasia of hepatic small-round-cell were observed in surgical specimens of a few rats at the 53rd week and first incidence of hepatic tumor was seen in the autopsy material of the 2.0% level at the 83rd week.<br>Summarizing from the results of neoplastic changes of livers, there were one case of hepatoma, five cases of hepatic adenoma including bile duct adenoma and seven cases of adenomatous or nodular hyperplasia in the 2.0% feeding level; one of hepatic adenoma, seven of adenomatous or nodular hyperplasia in the 1.0% feeding level; two of hepatic adenoma, five of adenomatous or nodular hyperplasia in the 0.5% feeding level; and four of adenomatous or nodular hyperplasia in the control.<br>From these results carcinogenicity or tumorigenicity of Ponceau 3R was revealed in our experiment, too.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 7 (3), 211-221_1, 1966

    公益社団法人 日本食品衛生学会

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