ニューロン‐グリア間，ニューロン‐ニューロン間細胞接着分子：Ｎｇ‐ＣＡＭ

• Grumet Martin

  Department of Pharmacology, New York University Medical Center

• 田中 徹三

  中外製薬株式会社研開企画部

書誌事項

タイトル別名

• Ng-CAM, A Neuron-Glia and Neuron-Neuron Cell Adhesion Molecule.

抄録

The neuron-glia cell adhesion molecule (Ng-CAM) mediates both neuron-glia and neuron-neuron adhesion. It is synthesized in neurons from a 6kb mRNA as 200kDa forms which are cleaved to yield two components of 135kDa and 80kDa. Amino acid sequence analysis indicates that it contains six immunoglobulin domains and five fibronectin type III repeats, a transmembrane domain and a cytoplasmic region. Ng-CAM mediates neuron-neuron adhesion by a homophilic mechanism and neuron-astrocyte adhesion by a heterophilic mechanism. The protein is expressed on neurons and Schwann cells but not on astrocytes. It is most prevalent during development on cell bodies of migrating neurons and on axons during formation of nerves; Ng-CAM expression is greatly increased following nerve injury. Anti-Ng-CAM antibodies inhibited migration of granule cells along Bergmann glia in the cerebellar explants and fasciculation of neurites in outgrowths from explants of dorsal root ganglia. In summary, Ng-CAM on neurons can bind to Ng-CAM on adjacent neurons and to as yet unidentified ligands on astrocytes.

収録刊行物

• Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ

  Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 4 (15), 32-42, 1992

  FCCA(Forum: Carbohydrates Coming of Age)

キーワード

• L1/NILE
• cell adhesion molecules
• neural development
• neuron-neuron interaction
• neuron-glia interaction

詳細情報

• CRID: 1390001204371396736
• NII論文ID: 130003699075
• DOI: 10.4052/tigg.4.32
• ISSN: 18832113
• ISSN: 09157352
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可