骨形成因子（ＢＭＰ）と歯牙発生

DOI Web Site 参考文献84件
  • Peterková R.
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
  • Turecková J.
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
  • Lesot H.
    INSERM U-424, Institut de Biologie Médicale
  • Vonesch J.-L.
    Institut de Génetique et de Biologie Moléculaire et Cellulaire
  • Peterka M.
    Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic
  • Ruch J. V.
    INSERM U-424, Institut de Biologie Médicale
  • 利根川 あかね
    北里大学・理学部・生物科学科・分子発生学講座

書誌事項

タイトル別名
  • Bone Morphogenetic Proteins(BMPs) and Tooth Development.
  • ホネ ケイセイ インシ BMP ト シガ ハッセイ ガン ゲンブン

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抄録

Bone Morphogenetic Proteins (BMPs) exhibit multiple functions during development. They are assumed to play signaling roles in the mediation of epithelio-mesenchymal interactions during tooth development and repair. This review aims to survey the hitherto data on BMPs during tooth development with an attempt to stress a possible functional relationship between epithelial BMPs expression and regressive processes representing integral part of normal odontogenesis. During tooth development, BMPs gene transcription appears to be involved in early condensation and further differentiation of the dental mesenchyme and of its derivatives. The expression of BMPs transcripts in the dental epithelium, however, is specifically restricted both in space and time during prenatal development. In mouse, these sites of BMP-2, BMP-4 and BMP-7 transcripts mostly fit with the areas, where apoptosis has been reported during reduction or even elimination of specific dental epithelial cell populations: i. rudimental tooth primordia in the prospective mouse diastema, ii. the enamel knot, iii. ameloblasts, iv. the residual dental lamina (gubernaculum of the enamel organ). These data strongly suggest involvement of the BMP-4 in upregulation of apoptosis also during odontogenesis. A possible implication of other BMPs and their precise role in regressive processes should be investigated.

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