ＡＢＯ式血液型不適合妊娠における新生児赤血球の直接グロブリン試験陽性の意義について　　ＩｇＧサブクラスの検討

• 浮田 昌彦

  倉敷中央病院産婦人科

• 渡辺 幸子

  倉敷中央病院輸血センター

• 山田 紀子

  倉敷中央病院輸血センター

• 森分 智子

  倉敷中央病院輸血センター

• 渡辺 文江

  倉敷中央病院輸血センター

書誌事項

タイトル別名

• Significance of positive direct anti-globulin test of the cord red cells in ABO incompatible pregnancy. Studies on IgG subclasses.
• Studies on IgG Subclasses
• IgGサブクラスの検討

抄録

Direct antiglobulin test (DAT) and heat elution test were examined on the cord red cells of 257 A or B infants weighing over 2, 500g born to O mothers. DAT was positive in 43 infants (group I), while was negative in 95 infants which were detected anti-A and/or anti-B antibodies by elution test (group II), and remaining 119 infants were not detected any antibody in their eluates. IgG subclasses were determined in 138 infants of group I and group II. In 59 out of 131 infants without ABO hemolytic disease (ABO-HDN), all IgG subclasses were undetectable in their eluates. In the eluates of 72 others, IgG1 was detected in 29/72, IgG2 in 63/72, and IgG3 was not detected in any infant. In 7 infants with ABO-HDN, DAT was positive in 4 cases and negative in 3. In conclusion, in DAT positive infants without HDN the only IgG subclasses bound to erythrocytes are IgG2 or IgG2 with a small amount of IgG1 which cannot cause hemolysis, and in DAT-positive ABO-HDN the amount of IgG1 is enough to cause hemolysis. In DAT-negative ABO-HDN, IgG3 is responsible for hemolysis even though in amounts undetectable by DAT.

収録刊行物

• 日本輸血学会雑誌

  日本輸血学会雑誌 34 (6), 601-606, 1988

  一般社団法人 日本輸血・細胞治療学会

詳細情報

• CRID: 1390282679884812800
• NII論文ID: 130003706717
• DOI: 10.3925/jjtc1958.34.601
• ISSN: 18838383
• ISSN: 05461448
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可