ジペプチジルペプチダーゼＩＶ阻害剤の関節炎発症抑制効果

• 田中 澄子

  田辺製薬 (株) 創薬研究所

• 杉田 尚久

  田辺製薬 (株) 創薬研究所

書誌事項

タイトル別名

• Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.

抄録

Dipeptidyl peptidase IV (DP IV, CD26) is a serine exopeptidase which selectively cleaves the penultimate proline residue of polypeptides. This enzyme is also expressed on activated T cells. To assess the relevance of DP IV in immunological disorders, we evaluated the pharmacological effects of specific DP IV inhibitors. A competitive inhibitor of DP IV, Lys (Z (NO₂) ) -thiazolidide suppressed mitogen-induced and antigen-induced proliferation of T cells. In vivo pharmacological effects were assessed by using alkyldiamine-and collagen-induced arthritis models, which share several pathological features with rheumatoid arthritis. A competitive inhibitor of DP IV (Lys (Z (NO₂) ) -thiazolidide), an irreversible inhibitor (Ala-Pro-nitrobenzoyl hydroxylamime), and a transition state substrate analog of DP IV (Ala-boroPro) suppressed alkyldiamine-induced arthritis. Ala-boroPro also suppressed collagen-induced arthritis. These results suggest that DP IV may play a role in the pathogenesis of certain inflammatory diseases through immune regulation.

収録刊行物

• 炎症

  炎症 18 (3), 199-202, 1998

  日本炎症・再生医学会

キーワード

• <I>dipeptidyl peptidase IV</I>
• <I>CD26</I>
• <I>protease inhibitor</I>
• <I>arthritis</I>

詳細情報

• CRID: 1390282679762402432
• NII論文ID: 130003709552
• NII論文ID: 10009359144
• NII書誌ID: AN00357213
• DOI: 10.2492/jsir1981.18.199
• ISSN: 18844006
• ISSN: 03894290
• Web Site: https://search.jamas.or.jp/link/ui/1998221871
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可