鼻副鼻腔疾患における鼻処置前後の鼻腔容積変化について

• 竹野 幸夫

  広島大学医学部耳鼻咽喉科学教室

• 平田 したう

  広島大学医学部耳鼻咽喉科学教室

• 平川 勝洋

  広島大学医学部耳鼻咽喉科学教室

• 夜陣 紘治

  広島大学医学部耳鼻咽喉科学教室

• 川本 浩子

  公立三次中央病院耳鼻咽喉科

書誌事項

タイトル別名

• CHANGE OF NASAL AIRWAY VOLUME BY TOPICAL NASAL DECONGESTANT IN PATIENTS WITH NASAL ALLERGY AND CHRONIC SINUSITIS
• AN OBJECTIVE STUDY WITH ACOUSTIC RHINOMETRY
• Acoustic Rhinometry による検討

抄録

In this prospective study, we investigated changes to nasal airway patency in the immediate response to the topical nasal decongestant, tramazoline hydrochloride, in patients with various nasal diseases. The study was carried out on the following groups: the control group (n=15), the nasal allergy group against house dust mite (n=30), the chronic sinusitis group (n=25), and the laser cauterization group (n=12). The chronic sinusitis group was further subdivided into two groups whether visible nasal polyps existed in the nasal cavity. We employed acoustic rhinometry as an objective method, and the nasal cavity volume (NCV) and the minimum cross-sectional area (MCA) were calculated before and 10 minutes after nasal sprays.<br>In untreated condition, the average NCV in the severe nasal allergy group was 6.63cm³, which was significantly lower than that in the control group (7.8cm³). Further analysis indicated that the reduced NCV in this group was mainly due to obstructive changes to the first 3cm area of the nasal cavity. No significant difference in the untreated NCV was observed in the other groups.<br>Pharmacologic decongestion caused increased nasal patency by 56% from the baseline NCV values in the control group, 42% in the nasal allergy group, 26% in the sinusitis without nasal polyps group, 30% in the sinusitis with nasal polyps group, and 10% in the laser group. The reduction in responsiveness was statistically significant in the sinusitis groups (p<0.05) and in the laser group (p<0.01). Changes to the MCA also showed close correlation with those to the NCV detected in each group. On the other hand, the degree of changes to the cross-sectional area around the nasal valve region remained within 10% in all groups. The results presented in this study demonstrate that acoustic rhinometry is a valuable method for the objective assessment of nasal patency. The pharmacological effect of tramazoline seems to depend on the anatomical features of the nasal cavity, aging, and the pathological changes to the nasal mucosa as well as therapeutic effects against nose diseases.

収録刊行物

• 日本鼻科学会会誌

  日本鼻科学会会誌 38 (2), 223-229, 1999

  日本鼻科学会

キーワード

• acoustic rhinometry
• nasal allergy
• chronic sinusitis
• nasal patency
• tramazoline hydrochloride

詳細情報

• CRID: 1390282679713347712
• NII論文ID: 130003720609
• DOI: 10.7248/jjrhi1982.38.2_223
• ISSN: 18837077
• ISSN: 09109153
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可