Ｃ型慢性肝炎に対しインターフェロン‐β治療を行った血液透析患者の１例　ＩＦＮ‐β薬物動態の検討

DOI 被引用文献2件 参考文献31件

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タイトル別名
  • Treatment of chronic hepatitis C with interferon .BETA. in a hemodialysis patient-optimal concentration of interferon .BETA. for a hemodialysis patient.
  • optimal concentration of interferon β for a hemodialysis patient
  • IFN-β薬物動態の検討

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A 36-year-old male patient with chronic renal failure complicated by chronic hepatitis C had been on maintenance hemodialysis since September 1993. He was admitted to our hospital to receive interferon (IFN) therapy for HCV infection prior to living donor-related renal transplantation. The concentration of HCV-RNA in serum was 8.4 Meq/ml by branched DNA assay, HCV genotype was 2a. IFN-β was chosen for treatment because not only IFN-β could be administered intravenously through the blood access for hemodialysis but also the half-life of IFN-β was short. To evaluate changes in the IFN-β concentration, 600 MIU IFN-β was preliminary infused for 3 minutes. The serum concentration of IFN-β raised up to 25600IU/ml and hypotension was appeared. Thus, we considered that drip infusion for 60 min was reasonable in this case. By drip infusion, the IFN-β concentration was not so high. After discharge, his headache worsened. So, IFN-β administration was stopped on day 71 due to neurological side effects. After IFN-β treatment ceased, HCV-RNA became positive again. Renal transplantation was performed 9 months later, and. liver dysfunction had not developed. In hemodialysis patients as well as others, IFN-β treatment by drip infusion is considered an acceptable method of achieving an appropriate concentration. However, in our case, IFN-β treatment was stopped due to its side effect, and so we must be more careful in administering IFN-β therapy to hemodialysis patients.

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