Human immunodeficiency virus(HIV)陽性女性に発生した子宮頚部異形成の1例

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  • Cervical dysplasia in a woman with human immunodeficiency virus.

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Background: The incidence of cervical cancer or cervical intraepithelial neoplasia (CIN) increases in patients infected by the human immunodeficiency virus (HIV), although few such cases have been reported in Japan.<BR>Case: A 28-year-old Japanese woman with HIV infection was referred to our department after becoming pregnant. Evacuation was conducted due to a low CD 4-positive lymphocyte count. Cervical cytology showed dyskaryotic cells with mild nuclear atypia. Colposcopic impression was dysplasia, and punch biopsy of the uterine cervix revealed mild dysplasia. Human papillomavirus (HPV) DNA was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). She received combination antiretroviral therapy, and CD 4 increased. She had an elective cesarean-section delivery at age 31. Cervical cytology and colposcopy showed no evidence of dysplasia and HPV DNA was negative after delivery.<BR>Conclusion: Cervical cancer screening is recommended for all women with HIV infection. Sexually transmitted disease (STD) including HPV should also be checked for.

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