Diversity myoepithelial cells of salivary gland pleomorphic adenoma-An ultrastructural and immunohistochemical study-
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- KATO Taku
- Division of Pathology, Funabashi Municipal Medical Center
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- MATSUMOTO Takashi
- Department of Pathology, Nihon University School of Dentistry at Matsudo
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- TAKAHASHI Hisao
- Division of Pathology, Funabashi Municipal Medical Center
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- TOKUIZUMI Miyuki
- Division of Pathology, Funabashi Municipal Medical Center
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- SUWA Tomoko
- Division of Pathology, Funabashi Municipal Medical Center
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- SHIMIZU Tatsuichiro
- Division of Pathology, Funabashi Municipal Medical Center
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- UEHARA Toshitaka
- Division of Pathology, Funabashi Municipal Medical Center
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- KUYAMA Kayo
- Department of Pathology, Nihon University School of Dentistry at Matsudo
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- YAMAMOTO Hirotsugu
- Department of Pathology, Nihon University School of Dentistry at Matsudo
Bibliographic Information
- Other Title
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- 多形腺腫における筋上皮細胞の多様性―特に電子顕微鏡的および免疫組織化学的検討を中心に―
- An ultrastructural and immunohistochemical study
- 特に電子顕微鏡的および免疫組織化学的検討を中心に
Abstract
Objective: The diversity of myoepithelial cells of pleomorphic adenoma in salivary gland was confirmed by ultrastructural and immunohistochemical studies.<BR>Study Design: 5 cases of pleomorphic adenoma diagnosed by cytology and histology were searched in ultrastructural observation and immunohistochemical staining (cytokeratin, GFAP, vimentin, S-100 protein and SMA).<BR>Results: (1) Cells constituting a pleomorphic adenoma were classified into ductal and other cells. Ductal cell features resemble intercalated intercalated duct cells of the normal salivary gland, while other cells resembled normal myoepithelial cells.<BR>(2) Other cells showed changes, and round to oval cells with several desmosomes and weakly positive for cytokeratin were epithelial.(3) Spindle to squamous metaplastic cells showed normal myoepithelial cell features.(4) Asteroid to small round single cells had pinocytotic vesicles, glycogen, and proteoglycan granules in cytoplasm, strong positivity for GFAP, vimentin, and mesenchymal S-100 protein and resembled chondroid metaplastic cells.(5) Focal cells of ductal cells were observed to be the reserve cells rich in glycogen and intermediate filaments in cytoplasm.<BR>Conclusion: The occurrence of this tumor was considered most intercalated duct cells in the salivary gland. Diverse cell changes were modified myoepithelial cells that showed morphological features in spindle, round, and chondroid metaplastic cells, and cells showed a diversity of character.
Journal
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- The Journal of the Japanese Society of Clinical Cytology
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The Journal of the Japanese Society of Clinical Cytology 45 (1), 43-49, 2006
The Japanese Society of Clinical Cytology
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Details 詳細情報について
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- CRID
- 1390001204695206016
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- NII Article ID
- 130003759045
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- ISSN
- 18827233
- 03871193
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed