Potential Antimetabolites. IV. Synthesis of 2, 6-Bis-alkylthiopurine Ribosides and their Selective Substitution by Nucleophilic Reagents

DOI Web Site PubMed
  • 池原 森男
    Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido Uninersity
  • 上田 亨
    Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido Uninersity
  • 堀川 純子
    Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido Uninersity
  • 山崎 晤弘
    Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido Uninersity

この論文をさがす

抄録

2, 6-Bis-methylthio-and 2, 6-bis-benzylthio-9-(2', 3', 5'-tri-O-benzoyl)-β-D-ribofuranosylpurines were synthesized by the condensation of chloromercury salt of 2, 6-bisalkylthiopurines with 2, 3, 5-tri-O-benzoyl-D-ribofuranosyl chloride. The transformation to 6-dimethylamino-and 6-methylamino-9-β-D-ribofuranosylpurine by the successive amination and desulfurization was achieved.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ