Studies on decomposition and stabilization of drugs in solution,13

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  • Studies on Decomposition and Stabilization of Drugs in Solution. XIII. On Sodium Lauryl Sulfate.

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1) Sodium lauryl sulfate (SLS) was hydrolysed in acidic solution at a high temperature, and the rate of hydrolysis was dependent on not only H+ concentration but also SLS. concentration. It was recognized that the rate of reaction was increased strikingly in the region of a certain concentration of SLS. 2) When the Critical micelle concentration (CMC) of SLS was determined by solubilization method with dye (Sudan III), it was approximately coincident with region of a certain concentration where the rate of reaction increased strikingly. 3) On the contrary to acidic solution, in alkaline solution, SLS above the CMC was a little more stable than that of below.

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