Studies on Seven-membered Ring Compounds. VIII. Syntheses of 5-Nitrosotropolone Derivatives.
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抄録
3-Substituted 5-nitrosotropolone (IIIa∼c), 7H-cyclohepta [b] pyrazin-7-one oxime (VIIIa, b), 8H-cyclohepta [b] quinoxalin-8-one oxime (IXa∼c), 9H-cyclohepta [b] naphtho [2, 3-e] pyrazin-9-one oxime (X), 5-nitrosotropolone guanidine adduct (XI), 2-(2-acetylhydrazino)-5-nitrosotropone (XII and its analogues) and 2-(2-troponylhydrazino)-5-nitrosotropone (XIV) were synthesized according to the schemes shown in Chart 1, 2, and 3. In addition, some reactions related to IIIa and IIIc were described. Among these derivatives, 2-(2-isonicotinoylhydrazino)-5-nitrosotropone and its N-oxide showed remarkable anti-tumor activities on ascitic and solid forms of Ehrlich tumor and Sarcoma 180.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 11 (11), 1423-1431, 1963
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390282679148533120
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- NII論文ID
- 110003619037
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 14090592
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可