Synthetic Studies on Sorigenins. VI. Synthesis of γ-Lactone of 3-Hydroxymethyl-1, 6, 8-trimethoxy-2-naphthoic Acid (α-Sorigenin Dimethyl Ether). (1).

• 堀井 善一

• 加多木 豊之

• 田村 恭光

抄録

The lithium aluminum hydride reduction of the half ester VIII, obtained by alcoholysis of 1, 6, 8-trimethoxy-2, 3-naphthalenedicarboxylic anhydride (VII), afforded two kinds of lactones of m. p. 185°and m. p. 202°, among which the former lactone of m. p. 185°was shown to be identical with natural α-sorigenin dimethyl ether, and the latter lactone of m. p. 202°with 3-hydroxymethyl-4, 5, 7-trimethoxy-2-naphthoic acid γ-lactone (X) prepared in the previous paper. Thus, the structure of α-sorigenin dimethyl ether was proved to be 3-hydroxymethyl-1, 6, 8-trimethoxy-2-naphthoic acid γ-lactone by synthetic means.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 11 (3), 312-317, 1963

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679148471552
• NII論文ID: 110003619077
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.11.312
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/11/3/11_3_312/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1964071852
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可