Studies on Acetylenic Compounds. XXXIII. A New Synthetic Method for Aminoacetylenic Compounds.

• 岩井 一成

• 由良 靖雄

抄録

A new and convenient route for the synthesis of various kinds of aminoacetylenes has been devised with Grignard reaction of aminoethers using acetylenemagnesium bromide. In the various cases examined, the yields range was 26∼76%. Both N, N-di (2-propynyl) amine- an 1, 4-di (2-propynyl) piperazine derivatives could be produced by this reaction, but in latter N, N-di (2-propynyl) methylamine derivative due to low reactivity of N, N-bis (butoxymethyl) methylamine (III) the reaction time was prolonged. Furthermore, by this reaction acetylenic aminoalcohols were obtained from cyclic aminoethers.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 11 (8), 1049-1054, 1963

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150348800
• NII論文ID: 110003619233
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.11.1049
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5888549
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/11/8/11_8_1049/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967053799
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可