Analytical Chemical Studies on Steroids. IV. The Zimmermann Reaction of 16- and 17-Oxosteroids

• 南原 利夫

• 加藤 元彦

抄録

The specificity of the Zimmermann reaction was examined with 38 kinds of 16- and 17-oxosteroids. The influences of environmental situation around oxo group on the reactivities were observed and interpreted in terms of stereochemistry. Of 16-substituted 17-oxosteroids only 16-monohalo derivative showed an exceptional behaviour giving a typical Zimmermann color. By treatment of the colored solution produced from 16α-bromodehydroisoandrosterone, the Zimmermann complex, 3β-hydroxy-16ξ-(2, 4-dinitrophenyl) androst-5-en-17-one, m.p. 186∼188°, was obtained and proved to be identical with that of dehydroisoandrosterone.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 13 (1), 78-86, 1965

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204168555392
• NII論文ID: 110003619461
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.13.78
• COI: 1:CAS:528:DyaF2MXnsVChug%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5864287
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/13/1/13_1_78/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967019774
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可