Constituents of Rhizoma nupharis. XXII. Structure of Nuphamine

• 荒田 義雄

• 大橋 力

抄録

A new alkaloid (I), C₁₅H₂₃O₂N has been isolated from Nuphar japonicum DC. and named nuphamine. The compound (III) obtained by the catalytic reduction after the chlorination of I with thionyl chloride is completely in accordance with (-)-desoxynupharamine, derived from nupharamine (IX). By the catalytic reduction of I with palladium-carbon, dihydronuphamine (V), (-)-deoxynupharidine (VI-A) and allodeoxynupharidine (VI-B) were prepared. VI-A and VI-B were also prepared from V. Judging from these reactions and the nuclear magnetic resonance spectra, the structure of I has been determined to be presented by the fromula VIII. The steric chemical correlations among the alkaloids, (-)-desoxynupharidine (VI-A), (-)-nuphamine (VIII) and (-)-nupharamine (IX) isolated from Nuphar iaponicum have been also achieved.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 13 (10), 1247-1251, 1965

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204169476224
• NII論文ID: 110003619482
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.13.1247
• COI: 1:CAS:528:DyaF28Xjs1Sltw%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5864707
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/13/10/13_10_1247/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1966057063
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可