Absorption and Excretion of Drugs. XXVI. Effect of Water-Soluble Bases on Rectal Absorption of Sulfonamides

• 掛見 喜一郎

• 有田 隆一

• 村西 昌三

抄録

The rates of absorption of sulfonamides were measured in the presence of a number of water-soluble bases. The absorption rates was reduced by these bases. This reduction depends mainly upon their decrease of lipid-vehicle partition. The differences existed in their absorption at incorporating the various water-soluble bases, and these differences are related to the dielectric constants of the bases : the larger their dielectric constant, the smaller the reduction of rectal absorption. The results suggest that the drug abosrption in the presence of water-soluble bases can be interpreted by the depression of the polarity in the vehicle.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 13 (8), 969-975, 1965

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172643072
• NII論文ID: 110003619689
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.13.969
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5867840
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/13/8/13_8_969/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1966064725
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可