Studies on Food Additives. X. The Metabolism of p-Ethoxyphenylurea in the Rabbit

• 赤木 満州雄

• 青木 勇

• 植松 孝悦

抄録

1. The metabolic fate of p-ethoxyphenylurea in the rabbit was studied. 2. About 40% of the dose was excreted as phenolic substances, presumably p-hydroxyphenylurea. The phenolic products were excreted as the unconjugated (7%), glucuronide (11%), and sulfate (23% of p-ethoxyphenylurea fed). p-Hydroxyphenylurea was isolated as its diacetyl dericative. The sulfate and glucuronide of p-hydroxyphenylurea were detected. 3. It was suggested that the main glucuronide of p-ethoxyphenylurea was N-glucuronide. This compound accounted for about 27% of p-ethoxyphenylurea fed. The N-glucuronide was isolated as crystals of both potassium and ammonium salts of p-ethoxyphenylurea N-glucuronide. 4. About 3% of the dose was excreted unchanged.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 14 (1), 1-9, 1966

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679149338368
• NII論文ID: 110003619721
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.14.1
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5920512
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/14/1/14_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1967071755
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可