Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2, 4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat

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The intestinal absorption of sulfisoxazole was reduced by replacing sodium ion in perfusion solution with potassium ion in vivo. The rates of intestinal transport of sulfonamide, sulfisoxazole and sulfisomezole, also, were decreased by replacing sodium ion in circulating solution with potassium ion in vitro. The transport rate and uptake of sulfisomezole in the intestine were decreased by DNP alone, and the combination of the replacing sodium ion with potassium ion and DNP. These of sulfisoxazole and sulfanilamide, however, were not affected by the same treatments.

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