Studies on the metabolism of sulfadiazine.-2-Quantitative separation of excrements in the human urine after administration of sulfadiazine
書誌事項
- タイトル別名
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- Studies on the Metabolism of Sulfadiazine. II. Quantitative Separation of Excrements in the Human Urine after Administration of Sulfadiazine
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Excretion of sulfadiazine, N4-acetylsulfadiazine, sulfadiazine-N4-glucuronide, sulfadiazine-N4-sulfonate, and sulfanilamide into human urine was separately determined by paper chromatography by the following method. One tenth ml. of urine obtained after oral administration of sulfadiazine was spotted lineary on a filter paper (Toyo Roshi No.51 40×40 cm.) and developed ascendingly with a solvent system of butanol saturated with water and a solvent of BuOH-AcOh-H2O(5 : 1 : 4) for about 20 hours. The paper was dried in air, portions corresponding to the products were cut out, and eluted descendingly with N/4 ammonium hydroxide. Each of these metabolites was hydrolyzed with hydrochloric acid and determined by the colorimetric method using the Ehrlich's reagent as sulfadiazine. The content was calculated from a calibration curve prepared beforehand. The amount excreted 48 hours after oral administration of 2 g. of sulfadiazine was 1620 mg., calculated as sulfadiazine, including 862 mg. of sulfadiazine, 730 mg.of N4-acetylsulfadiazine, 11 mg. of sulfadiazine-N4-glucuronide, 14 mg. of sulfadiazine-N4-sulfonate, and 5 mg. of sulfanilamide, calculated as sulfadiazine respectively.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 14 (7), 687-691, 1966
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679151087360
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- NII論文ID
- 110003619920
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8508744
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可