Bisbenzylisoquinoline alkaloids and related compounds.-11-Total synthesis of stereoisomeric mixture of magnoline

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  • Bisbenzylisoquinoline Alkaloids and Related Compounds. XI. Total Synthesis of Stereoisomeric Mixture of Magnoline

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The diamide (IX) was prepared by Schotten-Baumann reaction of 2-(3-methoxy-4-hydroxyphenyl) ethylamine with the diacid chloride (V), followed by ethoxycarbonylation. Cyclization gave the bisdihydroisoquinoline (XI), the dimethiodide of which, on reduction, gave a stereoisomeric mixture of magnoline or berbamunine (I).

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