Syntheses of 3-aminopropylguanidine derivatives(Notes)

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  • Syntheses of 3-Aminopropylguanidine Derivatives

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The fourteen compounds of 3-(substituted amino)propylguanidine were synthesized by reacting S-methylisothiourea sulfate with 3-(substituted amino)propylamine : 3-(substituted amino) propylamine having an aliphatic substituent group at 3-position were synthesized by reacting the aliphatic amine with acrylonitrile and by reducting with lithium aluminum hydride, while 3-(substituted amino)propylamine having an aromatic substituent group at 3-position, synthesized by the Ing-Manske modification of the Gabriel synthesis of primary amines.

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