Studies on Antiviral Agents. V. Synthesis and Antiviral Activity of N-Chloro Compounds.

• 由岐 英剛

• 岸川 虎比古

• 東平 靖雄

• 鈴木 清吉

• 佐野 文彦

• 早川 繁

抄録

N-chloro compounds were synthesized and their virus inactivating activity and probable mechanism of the action were investigated. It is likely that the N-chloro compounds oxidize the sulfhydryl groups of the viral protein coat to form disulfide, disulfoxide, and sulfinic acid resulting in inactivation of the virus. This action is nonspecific and irreversible, and is lost in the presence of serum proteins.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 15 (8), 1123-1128, 1967

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204173433088
• NII論文ID: 110003620298
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.15.1123
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5583167
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/15/8/15_8_1123/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1969002357
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可