A Novel Synthesis of Steroidal [2, 3-c] thiophenes

• 金子 秀彦

• 大和 譲

• 黒川 美貴雄

抄録

Steroids with a thiophene ring fused to the 2, 3 positions were synthesized. Condensation of 2-methoxymethylene-3-ketosteroids (Ia, Ib) with ethyl thioglycolate in the presence of sodium methoxide yielded the tetrahydrothiophene derivatives (Va, Vb), which were dehydrated to the corresponding androstano [2, 3-c] thiophene carboxylates (VIa, VIb) by treatment of acids. Hydrolysis, followed by decarboxylation of the carbethoxythiophenes gave the corresponding androstano [2, 3-c] thiophenes (Xa, Xb). Similarly androst-4-eno [2, 3-c] thiophenes and androstanc [16, 17-c] thiophenes were prepared.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 16 (7), 1200-1209, 1968

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172739968
• NII論文ID: 110003620634
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.16.1200
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/16/7/16_7_1200/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1970056318
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可