Studies on Absorption of Drugs. IV. Effects of Surface Active Agents on Intestinal Absorption of Drugs
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Effects of surface active agents (ionic and nonionic) on intestinal absorption of drugs were studied on three method, i. e., (1) circulation with surfactants, (2) preperfusion with surfactant solutions, followed by circulation of drug solution free from surfactants, and (3) feeding experiments of surfactants solutions, followed by circulation of drug solution. Effects of surfactants were reviewed from two points. One is the effect due to interaction of drugs with surfactants and the other effect due to degeneration of the intestinal mucosa. It is concluded that the absorption of ionized species of drugs were more decreased than that of unionized species in degenerated intestinal mucosa, except for ionic interaction between drugs and surfactants.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 17 (6), 1109-1114, 1969
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204173308160
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- NII論文ID
- 110003620982
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 5804464
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可