Studies on Steroid Conjugates. III. New Syntheses of 2-Methoxyestrogens

• 南原 利夫

• 本間 誠次郎

• 秋山 節子

抄録

The new synthetic routes leading to the 2-methoxyestrogens from the readily available compounds have been investigated. Utilization of both Friedel-Crafts and Baeyer-Villiger reactions with estrone and estradiol 3-methyl ethers gave the desired 2-methoxyestrogens in overall yield of ca. 50%. Fries rearrangement with estrone acetate and Friedel-Crafts reaction with 2-methoxy-3-deoxyestrogens were also undertaken. The chemical shifts of the aromatic protons of the 2, 3-substituted estratrienes are collected in Table I and II.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 18 (3), 474-480, 1970

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172006656
• NII論文ID: 110003632319
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.18.474
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/18/3/18_3_474/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1971046208
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可