Some Observations on the Cardiovascular Effects of 9-Substituted Berberines

• 福田 英臣

• 渡辺 和夫

• 工藤 佳久

抄録

A comparative study of the effect of berberine and its 9-substituted compounds (I, R=OH ; II, berberine, R=OCH₃ ; III, R=OC₄H₉ ; IV, R=OC₅H₁₁ ; V, R=OC₈H₁₇ ; VI, R=OC₁₂H₂₅) on blood pressure of rats showed that substitution of OC₄H₉ or OC₅H₁₁ for OCH₃ of berberine prolonged the transient hypotensive activity of berberine, whereas substitution by OH caused a slight hypertension. The dose of III or IV, which caused hypotension, was found to inhibit cardiac function in rats, whereas II had no effect on it. II, III, and IV decreased the beating rate in isolated perfused toad heart. Only II was found to have acetylcholine-potentiating action in frog muscle as well as guinea-pig small intestine in vitro. In the same preparations III and IV, contrariwise, inhibited acetylcholine action. In spinal rats, any response in blood pressure was not observed after the injection of each of the test compounds. From these results, possible mechanism of action of the test compounds is discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 18 (7), 1299-1304, 1970

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172414080
• NII論文ID: 110003654612
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.18.1299
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 5453973
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/18/7/18_7_1299/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1971045393
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可