Synthesis of Aminoisoquinolines and Related Compounds. X. A Modified Synthesis of dl-Cularine

• 石渡 三郎

• 藤井 起二

• 宮司 進之

• 佐藤 吉之

• 板倉 啓壹

抄録

The Bischler-Napieralski reaction of the phenethylamides (VIIa and VIIb) gave respectively the 6-ethoxycarbamido-3, 4-dihydroisoquinolines, formed by the cyclization at the position para to the ethoxycarbamido group, and both 3, 4-dihydroisoquinolines were converted to the 6-aminoisoquinolines (Xa and Xb). Each 7, 8-disubstituted isoquinolines (XIIa and XIIb), prepared by deamination reaction of Xa and Xb, were submitted to the Ullmann reaction to give respectively 6-methoxy-1-methyl-1, 2, 3, 12, 12a-pentahydrobenzoxepino [2, 3, 4-i, j] isoquinoline (XIII) and dl-cularine (Ia).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 18 (9), 1850-1855, 1970

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679148839424
• NII論文ID: 110003632517
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.18.1850
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/18/9/18_9_1850/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1971087233
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可