Studies on the metabolic fate and the pharmacokinetics of 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine (BCP) in man. V. Pharmacokinetics of BCP in man and in rabbit following intravenous administration of BCPNa

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  • Studies on the Metabolic Fate and the Pharmacokinetics of 5-<I>n</I>-Butyl-1-cyclohexy1-2, 4, 6-trioxoperhydropyrimidine (BCP) in Man. V. Pharmacokinetics of BCP in Man and in Rabbit following Intravenous Administration of BCPNa

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In order to support the application of the model 1 to simulate the behavior of 5-nbutyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in man, further studies were carried out independently in man and in rabbits.<BR>The human plasma concentration and urinary excretion after the intravenous administration of BCPNa in a clinical test were simulated well by the model 1 with the same order of values for the rate constants as in the oral administration.<BR>Then, using rabbits, BCP in organs and tissues along with the plasma concentration and urinary excretion were determined and compared with the simulated values by the model 1.<BR>After correction for the mass balance, the tissue amounts of BCP were simulated fairly well.<BR>These results indicated the applicability of the model 1 both in man and in rabbits.

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