Studies on L-Ascorbic Acid Derivatives. VI. Phosphorylation of L-Ascorbic Acid and Its Isopropylidene Derivative

• NOMURA HIROAKI

  Research and Development Division, Takeda Chemical Industries, Ltd.

• SHIMOMURA MASAFUMI

  Research and Development Division, Takeda Chemical Industries, Ltd.

• MORIMOTO SHIRO

  Research and Development Division, Takeda Chemical Industries, Ltd.

抄録

Phosphorylation of L-ascorbic acid and its 5, 6-isopropylidene acetal with phosphoryl chloride under conditions using water as solvent and pyridine as base yielded almost quantitatively and selectively L-ascorbic acid 3-phosphate which has been a useful compound in cosmetic field. The reaction is suitable for manufacturing of the phosphate in a good yield. The effects of changes in solvent and base upon the phosphorylation reaction are also discussed by comparison of the yield and the composition of the products.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 19 (7), 1433-1437, 1971

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204169940864
• NII論文ID: 130003766865
• DOI: 10.1248/cpb.19.1433
• COI: 1:CAS:528:DyaE3MXkvFyktL8%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/19/7/19_7_1433/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可