Studies on Pyrazine Derivatives. I. Synthesis of Pyrazinoylmorpholine and Related Compounds

• UCHIMARU FUMIHIKO

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• OKADA SEIZABURO

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• KOSASAYAMA AKIRA

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

• KONNO TSUNEO

  Research Laboratories, Daiichi Seiyaku Co., Ltd.

抄録

For the evaluation of biological activities, 4-pyrazinoylmorpholine (II) and many new compounds have been synthesized from the N-oxide of II. The reactions of 2-(4-morpholinocarbonyl) pyrazine 4-oxide (IV) with halogenation reagents were examined, and the main product was proved to be 6-chloro-2-(4-morpholinocarbonyl) pyrazine (VII) by correlating the product to the known 2-amino-6-chloropyrazine (XIV).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 19 (7), 1337-1343, 1971

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204173606016
• NII論文ID: 130003766876
• DOI: 10.1248/cpb.19.1337
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/19/7/19_7_1337/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可