Pyrimidine Derivatives and Related Compounds. XIV. The Synthesis of N-Substituted Pyrazolo [3, 4-<I>d</I>] pyrimidines from Pyrimidine Derivatives
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- SHIGEO SENDA
- Gifu College of Pharmacy
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- KOSAKU HIROTA
- Gifu College of Pharmacy
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- GUANG-NA YANG
- Gifu College of Pharmacy
抄録
Reactions of 1, 3-disubstituted 6-chloro-5-formyluracils (1) with phenylhydrazine or methylhydrazine giving 1, 5, 7-and 2, 5, 7-trisubstituted 4, 6-dioxo-4, 5, 6, 7-tetrahydropyrazolo [3, 4-d] pyrimidines (3, 7 and 4) were investigated in detail. It was found out that 5-formyl group in 1 was more reactive than that 6-chloro group. Thus, under cold condition, the reaction of 1 with phenylhydrazine yielded Schiff's bases (2). Upon heating, 1 with equimolar or two equivalent moles of phenylhydrazine gave isomeric compounds, 3 and 4, which were also prepared by other routes. Reactions of methylhydrazine with 1 were also investigated. Furthermore, the Schiff's bases were made to react with other kinds of hydrazines. The reaction products showed that substituent at 1- or 2-position of the products (4, 7) depended on the kind of hydrazine used later.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 20 (2), 399-403, 1972
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679148265344
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- NII論文ID
- 130003766950
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- COI
- 1:CAS:528:DyaE38XhsVSks74%3D
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可