Synthesis of Pyrrolopyrimidines and Thienopyrimidines

• OGURA HARUO

  School of Pharmaceutical Sciences, Kitasato University

• SAKAGUCHI MASAKAZU

  School of Pharmaceutical Sciences, Kitasato University

• TAKEDA KAZUYOSHI

  School of Pharmaceutical Sciences, Kitasato University

Abstract

7-Substituted 1, 3-dimethyl-7H-2, 4, 6-(5H, 6H) pyrrolo [2, 3-d] pyrimidinetriones (IIIa, b, c) were prepared from 6-amino-1, 3-dimethyluracil (I) and ethyl α-bromoacetate. Reactionof I and α-bromo-ketones afforded 6, 7-disubstituted 1, 3-dimethyl-7H-2, 4-pyrrolo-[2, 3-d] pyrimidinediones (IV, V, VI). On the other hand, reaction of 6-mercapto-1, 3-dimethyluracil (VIII) and cc-bromocarbonyl compound afforded thieno [2, 3-d] pyrimidines (X, XI).

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 20 (2), 404-408, 1972

  The Pharmaceutical Society of Japan

Keywords

• Drug Discovery
• General Chemistry
• General Medicine

Details

• CRID: 1390001204173245056
• NII Article ID: 130003766976
• DOI: 10.1248/cpb.20.404
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/20/2/20_2_404/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed