Studies on the Sulfur-containing Chelating Agents. XXXV. Determination of Acid Dissociation Constants of N-Phenyl- and N-Ethyl-β-mercaptocin-namamide and Thiodibenzoylmethane by Solvent Extraction Method

• 横山 陽

• 千熊 正彦

• 田中 久

抄録

Acid dissociation constants and partition coefficients of N-phenyl-β-mercaptocinnamamide (I), N-ethyl-β-mercaptocinnamamide (II) and monothiodibenzoylmethane (III) were determined by the solvent extraction method in various solvent systems, by the use of ³⁵S-labeled species of these chelating agents. The results are considerably different from those obtained spectrophotometrically. The hydrolysis and the oxidation were found to occur in aqueous organic solvent in parallel with the dissociation in I and II, and III respectively. The solvent extraction method was regarded to be preferable than the spectrophotometric method, because the influences of the side reactions can be made very little by the use of solvent extraction method.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 20 (9), 2000-2007, 1972

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204172805632
• NII論文ID: 110003621404
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.20.2000
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/20/9/20_9_2000/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1973085801
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可