Pyrimidine Derivatives and Related Compounds. XVIII. Studies in the Synthesis and Pharmacological Activities of 2, 4-Dioxo-1, 2, 3, 4, 6, 7-hexahydro-5H-cyclopenta [d] pyrimidine Derivatives

• 千田 重男

• 広田 耕作

• 前野 恭治

抄録

Syntheses of 3-substituted 2, 4-dioxo-1, 2, 3, 4, 6, 7-hexahydro-5H-cyclopenta [d] pyrimidines (3-substituents : methyl, cyclohexyl, phenyl) from 2-ethoxycarbonylcyclopentanone were investigated. These compounds were alkylated in 1-position to give 1, 3-disubstituted pyrimidine derivatives (1-substituents : CH₃, CH₂COOR, CH₂CONR₂, CH₂CH₂NR₂). Their acute toxicities and analgetic, antipyretic, and antiinflammatory activities were tested.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 21 (9), 1894-1900, 1973

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679153497472
• NII論文ID: 110003621601
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.21.1894
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 4785103
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/21/9/21_9_1894/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1974025114
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可