Studies on Heterocyclic Compounds. XII. A Novel Synthesis of 5-Oxo- and 7-Oxo-pyrido [2, 3-d] pyrimidines
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A simple synthesis of pyrido [2, 3-d] pyrimidine derivatives as an antitumor agent was reported. Reaction of 6-amino- and 6-(substituted) amino-1, 3-dimethyluracil (I) with dimethyl acetylenedicarboxylate in methanol afforded a mixture of 5-oxo- and 7-oxopyrido-[2, 3-d] pyrimidines and an open-chain intermediate. This intermediate was proved to be 5-substituted 6-aminopyrimidine (VIa), and to be cyclized to 7-oxopyrido [2, 3-d] pyrimidine (VIIIa). On the other hand, 5-oxo compounds were obtained from the reaction of I with diketene or ethyl acetoacetate.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 21 (9), 2014-2018, 1973
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204176739968
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- NII論文ID
- 110003621616
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可