Heterocycles related to Nucleotides. VI. Photochemistry of Thiopyrimidines : Photoreduction of Thiouracils and Thiouridines with Sodium Borohydride

• 佐藤 英助

• 金岡 祐一

抄録

On ultraviolet irradiation in the presence of sodium borohydride, 4-thiouracil (1a), 4-thiouridine (1b) and 2-thiouracil (3a) were readily reduced to 2-oxohexahydropyrimidine (2a), its riboside (2b) and 1-(3-hydroxypropyl) thiourea (4), respectively. By controling the energies of the ultraviolet light in the region below 300 nm the selective photoreduction of these thiopyrimidines was demonstrated, while uracil and uridine were unaffected under these conditions. Photochemical behavior of the thiopyrimidines was discussed.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (4), 799-804, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679151001600
• NII論文ID: 110003633234
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.799
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/4/22_4_799/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975025639
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可