Studies on 1-Azabicyclo Compounds. XIX. Synthesis of Ten-membered Ring Amine Derivatives from 5-Methyl-10-nitromethyloctahydro-quinolizinium Iodide and Its Derivatives

• 荒田 義雄

• 菊池 鉄雄

• 高橋 峯夫

• 青木 正

抄録

Reaction of Δ^{1, 10}-hexahydroquinolizine (VI) with a combination of nitromethane and methyl iodide gave 5-methyl-10-nitromethyloctahydroquinolizinium iodide (VII), which, on treatment with lithium-liquid ammonia, gave the ten-membered ring amines, XIV and XV. Similar reduction of the N-acetyl methiodide (X) and the betaine (XI) derived from VII gave XVIII and XIX, respectively.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (5), 1003-1007, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390001204177783296
• NII論文ID: 110003654647
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.1003
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/5/22_5_1003/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1974112280
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可