Effect of Biliary Drainage on Bile Acid Conjugation with Taurine in Vitamin B<SUB>6</SUB>-Deficient Rats

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Feeding of a synthetic, vitamin B6-deficient diet for 7 weeks caused a marked increase in the ratio of glycine- to taurine-conjugated bile acids in the bile of rats. The highly elevated ratio, however, was reduced spontaneously by the elapsing time of biliary drainage, and the decrease in the ratio was accelerated by a subcutaneous administration of 2 g/kg of taurine. An intravenous injection of 5 mg/kg of sodium deoxycholate caused a temporary increase in the biliary secretion of taurodeoxycholic acid in both groups of normal and vitamin B6-deficient animals, and taurine loading prior to the deoxycholate-injection further augmented the increased secretion of this taurine-conjugated bile acid fraction. The glycodeoxycholic acid secretion in vitamin B6-deficient rats was not increased significantly after the deoxycholate-injection.

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