The use of N-hydroxy-5-norbornene-2,3-dicarboximide acitive esters in peptide synthesis.

• 藤野 政彦

• 小林 栄

• 大林 幹彦

• 福田 常彦

• 品川 進

• 西村 紀

抄録

N-Hydroxy-5-norbornene-2, 3-dicarboximide (HONB) was found to be an excellent reagent to be used in couple with N, N'-dicyclohexylcarbodiimide (DCC) for the peptide synthesis. Various racemization tests by the use of this reagent were conducted to see the degree of racemization during the peptide synthesis. The newly employed reagent (HONB) decreases racemization, prohibits formation of N-acylurea and affords peptides in excellent yields and a high state of purity. To evaluate this new reagent, luteinizing hormone releasing hormone (LH-RH) was prepared by the new active ester method.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (8), 1857-1863, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679145025664
• NII論文ID: 110003633373
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.1857
• COI: 1:CAS:528:DyaE2cXlt1Squrc%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• PubMed: 4609627
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/8/22_8_1857/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975052848
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可