Studies on bredinin. III. Chemical synthesis of bredinin. (A novel imidazole nucleoside).

• 林 満男

• 平野 孝夫

• 八十 昌夫

• 水野 公雄

• 上田 亨

抄録

Bredinin, a novel imidazole nucleoside, produced by Eupenicillium brefeldianum M-2166 was synthesized by the condensation of the trimethylsilyl derivative of 4 (5)-carbamoyl imidazolium-5 (4)-olate with 1, 2, 3, 5-tetra-O-acyl-β-D-ribofuranose in the presence of Friedel-Crafts catalysts (SnCl₄, TiCl₄) followed by deacylation. It was identical with natural bredinin. The absolute configuration was established as 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-olate.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (1), 245-246, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679147238784
• NII論文ID: 110003621675
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.245
• COI: 1:CAS:528:DyaE2MXhsVSnsL8%3D
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/1/23_1_245/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975084592
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可