Kinetics of and mechanism of transamination of thiamine in the presence of bisulfite.

• 小田切(蟹江) 陽子

• 上釜 兼人

• 池田 憲

抄録

The transamination reaction of thiazole moiety of thiamine (PyTh) by aromatic amine (A) in the presence of bisulfite (S) was studied kinetically. The reaction between PyTh and A was found to be second order with respect to PyTh and A, whereas the concentration of S was independent to the reaction rate. The reaction rate was linearly correlated to the pK_a value of A. The transamination product (PyA) was also degradated by S in second order as well as PyTh. The complexation between PyTh and A was also investigated as a possible proceeding process of the transamination reaction.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (1), 13-19, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679151140480
• NII論文ID: 110003621638
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.13
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/1/23_1_13/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975084848
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可