Amino acids and peptides. XV. A new synthesis of .ALPHA.-amino acids by amination of .ALPHA.-metalated carboxylic acids.

• 小栗 東明

• 塩入 孝之

• 山田 俊一

抄録

Amination of α-lithiated carboxylic acid salts was investigated using isovaleric acid mainly. Methoxyamine bearing a proper electronic character was the best aminating reagent, as shown in Table I. Several α-amino acids, e.g., valine, leucine, methionine, phenylalanine, and α-phenylglycine, were prepared by this new method, summarized in Table II. The synthesis of two new aminating reagents, 3, 5-dinitromesitoxyamine and 2-tetrahydropyranyloxyamine were described.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 23 (1), 167-172, 1975

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679150232064
• NII論文ID: 110003621658
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.23.167
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/23/1/23_1_167/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1975084953
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可